A PRAGMATIC APPROACH TO TREAT LUNG CANCER THROUGH LOADING THEAFLAVIN -3,3’-DIGALLATE AND EPIGALLOCATECHIN GALLATE IN SPANLASTIC

Lung cancer has the highest mortality rate as compared to other cancers. The anti-proliferative and antioxidant potential of epigallocatechin gallate (EGCG) Theaflavin -3,3’-digallate (TF3) can play a major role in treatment if delivered efficiently. To improve chemical stability medicinal EGCG TF3 respiratory tract, spanlastic is developed which composed Tween-80, Span-60, cholesterol encapsulate inside its vesicular structure deliver it specifically target cells. layer will produce efficient penetration while tween-80 span-60 help easily deformability lowers interfacial tension hence, produces small Z-average diameter facilitates between layers nano-vesicular ensures APIs at alkaline pH (7.6) also increases cellular activity Ferric reducing powers values APIs. Better encapsulation efficiency safe consideration by MTT assay are advantages Spanlastic. lung cell loses ability apoptosis, revived with system addition, there be activation several properties such arrest, miR-210, suppression cyclin D1, inhibition MAPK, ERK, JAK-STAT their maximum potential. Furthermore, special type spacer pMDI canister order maximize drug delivery.